In a differential diagnosis, we excluded the mutations in diacylglycerol kinase epsilon (DGKE) gene, whose presence could be responsible for the renal pathology of thrombotic microangiopathy or MPGN [13,14] and cobalamin C disease, which may also present as HUS with renal TMA during infancy [15]. Here, DGKE is linked to primary membranoproliferative glomerulonephritis.