TLR4 and breast cancer: As shown by Gibson et al., CPT-11 (175 mg/kg) caused no significant changes on the expression of TLR-2, TLR-4, TLR-5 and TLR-9 in jejunum and colon epithelial cells within 120 h in breast cancer-bearing rats; however, the expression of TLR-4 and TLR-5 significantly decreased in jejunal crypts of rats at 96 and 120 h [59].