CNR1 and obesity due to melanocortin 4 receptor deficiency: -Obesity possibly via inducing loss of appetite or increase in metabolic rate (loss of fat mass) via interaction with corticotropin-releasing hormone (CRH), a known anorexigenic-Rimonabant inhibits CB1R activation which is responsible for lipogenesis-Tobacco addiction-Inhibition of cannabinoid-induced heroin-seeking behaviour in rats