CCN2 and scleroderma: A synthetic cannabinoid, WIN55,212-2, administered 1 mg/kg/day, demonstrated complete prevention of bleomycin-induced scleroderma in a murine model, while also downregulating markers of fibroblast activation such as including α smooth muscle actin and the profibrotic cytokines transforming growth factor (TGF)β, connective tissue growth factor (CTGF) and platelet-derived growth factor (PDGF)-BB [282].