TGFB1 and scleroderma: VCE-004.8, a non-thiophilic and chemically stable derivative of the CBD quinol and a dual agonist of PPARγ and CB2R, showed promising anti-fibrotic efficacy in a murine model of bleomycin-induced scleroderma, and demonstrated reduction in dermal thickness, reduction in blood vessels collagen accumulation, inhibition of mast cell degranulation, inhibition of macrophage infiltration in the skin, inhibition of TGFβ-induced Col1A2 gene transcription and collagen synthesis, and inhibition of TGFβ–mediated myofibroblast differentiation and wound-healing activity [242].