The consequences of such an ictal decrease in the LH input to the DRN are hard to predict since the neurochemical diversity of both LH and DRN is substantial [33,34], nevertheless, the firing increase observed in putative 5-HT neurons during absence seizures [16] and decreases in identified 5-HT neurons [15] are probably the consequence of LH inputs. Here, PLOD1 is linked to Generalized non-motor (absence) seizure.