TBL1X and gestational diabetes: Further investigations with HTR-8 cells co-transfected with miR-138-5p inhibitor and TBL1X siRNA indicated that miR-138-5p could inhibit the migration and proliferation of HTR-8 trophoblasts by targeting TBL1X. Both mRNA and protein levels of TBL1X were significantly up-regulated in GDM placentas and a significant negative correlation between the expression of miR-138-5p and TBL1X mRNA was observed.