NLRC5 and Helicobacter pylori infectious disease: However, by taking advantage of NLRC5-deficient macrophages, and of knockout mice with nonfunctional Nlrc5 within the myeloid cell lineage, the authors found that NLRC5 negatively modulates the production of proinflammatory cytokines, including BAFF and protects against the formation of mucosal B cell lymphoid tissue formation in response to chronic Helicobacter infection in mice [33].