Several factors like reduced expression of epithelial markers E-cadherin and occludin and increased expression of mesenchymal markers vimentin, fibronectin and N-cadherin, tumor microenvironment, hypoxia and signal transduction pathways (WNT, Notch, Hedgehog) can trigger EMT, leading to drug resistance [86]. The gene discussed is FN1; the disease is neoplasm.