Although EphA4 activation has been directly or indirectly involved in different types of cell death, such as NIH 3T3 cells, glioblastoma multiform tumoral cells, retinal ganglion cells and endothelial cells [36,37,38,39], this was the first time that the novel effect of EphA4 on motor neuron survival in MND had been reported. Here, EPHA4 is linked to mild neurocognitive disorder.