Finally, other post-translational modifications of G3BP1 can also modulate SG assembly, such as methylation by the oncogenes PRMT1 and 5, which are highly expressed in HCC and impair SG assembly [48,49,50] or demethylation by JMJD6 (Jumonji domain-containing 6), a tumor-promoting histone arginine demethylase favoring SG assembly and also overexpressed in HCC [37]. This evidence concerns the gene G3BP1 and hepatocellular carcinoma.