For example, PRMT1, a protein arginine methyltransferase overexpressed in HCC, promotes carcinogenesis, but in the meantime, methylates UBAP2L on the RGG motif, thereby inhibiting SG formation [40,48,49,50] and thus questioning the necessity to assemble SGs for the oncogenic functions of UBAP2L. The gene discussed is PRMT1; the disease is hepatocellular carcinoma.