The transcription activator WDR11 (chr 10q26.12) was first found to be mutated in patients affected by normosmic CHH and KS in 2010, and a synergistic relationship between WDR11 and homeodomain transcription factor EMX1, involved in the development of olfactory neurons, was described [152]. The gene discussed is WDR11; the disease is cartilage-hair hypoplasia.