The analysis of NF1-associated tumor progression from PN to MPNST found biallelic NF1 mutations in all tumor stages, chromosome 17p (TP53) loss in primary MPNST and metastasis, but lack of CDKN2A deletions or epidermal growth factor receptor (EGFR) amplifications [24]. Here, EGFR is linked to malignant peripheral nerve sheath tumor.