The analysis of NF1-associated tumor progression from PN to MPNST found biallelic NF1 mutations in all tumor stages, chromosome 17p (TP53) loss in primary MPNST and metastasis, but lack of CDKN2A deletions or epidermal growth factor receptor (EGFR) amplifications [24]. The gene discussed is CDKN2A; the disease is malignant peripheral nerve sheath tumor.