Still, under hypoxic conditions, the degradation process is attenuated and HIF-α localization shifts from the cytoplasm to the nucleus, thus regulating cells metabolism, division and avoidance of apoptosis, tumor cell invasion and metastasis, as well as the expression of pro-angiogenic factors, including vascular endothelial growth factor (VEGF) [54]. The gene discussed is VEGFA; the disease is neoplasm.