Somatic mutations in the Polycomb repressive complex 2 (PRC2) components-Embryonic Ectoderm Development (EED) and Suppressor of Zeste 12 Protein Homolog (SUZ12) were reported in NF1-associated and sporadic MPNST [22,29,30]. The gene discussed is NF1; the disease is malignant peripheral nerve sheath tumor.