HSPG2 and cancer: Consistently, our in vivo results show that SCS-inhibited tumor growth mainly inhibits the proliferation of cancer cells by inhibiting the receptor protein (HSPG2) on the cell membrane and activating the gene/protein expression in PI3K-Akt signaling pathways, promoting the expression of apoptosis-related genes (Bad) and blocking cell cycle (P21, CDK2, CCNE1 and MCM2) (Figure 7).