MTHFR and hepatocellular carcinoma: Another meta-analysis paper reported in 2014 that MTHFR C677T polymorphism was significantly associated with an increased HCC risk in Asians but not in Caucasians [21], and in 2015 another meta-analysis also reported that MTHFR A1298C polymorphism might be related to an increased risk of HCC in Asians [22].