Important signaling pathways involved in HCC, such as β-Catenin pathway [56], Src-dependent phosphatidylinositol-3 kinase pathway (PI3K/AKT) pathway [57], Ras-Raf-mitogen activated protein kinase (MAPK) pathway [57], nuclear factor kappa B (NF-κB) pathway [58,59], Janus kinase/STAT (JAK/STAT) pathway [60] and protein kinase C (PKC) pathway, have all been reported to be aberrantly activated by HBx [61,62]. This evidence concerns the gene SOAT1 and hepatocellular carcinoma.