NLRP3 and gout: cAMP (cyclic Adenosine MonoPhosphate) signaling pathway: The increased cAMP level debilitated the MSU (Mono Sodium Urate)-induced activation of the Nod-like receptor protein 3 (NLRP3) signaling pathway, indicating the vital role of cAMP in the regulation of P2Y14 receptor (P2Y14R)-mediated gouty arthritis [55].