We also observed hypomethylation in two other genes involved in NOTCH signaling: DTX1 and NCOR2. Mutations in the NOTCH1 gene are frequent in CLL [4,5,6,7,8,9,10] and NOTCH signaling was associated with CLL progression [66,67,68]. The gene discussed is NOTCH1; the disease is B-cell chronic lymphocytic leukemia.