These 12 DMRs were associated with eight genes: ACOX3, ADAT3, ARID3A, FAM174B, NOTCH1, RGPD8, SCAMP4, and XXYLT1. IKAROS is involved in B cell development [59] and has previously been implicated with CLL [70]. Here, IKZF1 is linked to B-cell chronic lymphocytic leukemia.