Eleven DMRs (16%) were located at ten unique promoter regions (BCL9L, HTRA3, HPCAL1, IL17C, RGPD8, NCOR2, LCN10, AC107959.1, FAM1748, TGFBR3) and two genes (HTRA3 and FAM1748) had higher expression and hypomethylated promoters in CLL patients with SF3B1mut compared to SF3B1WT (Table S2). The gene discussed is RGPD8; the disease is B-cell chronic lymphocytic leukemia.