Two transgenic mouse lines mimicking retinal degeneration associated with ciliopathy of the photoreceptors, such as the Fam161atm1b/tm1b (Fam161a knockout) mouse and the Bardet Biedl Syndrom-10 (BBS10 KO mice), also presented isolated photoreceptors with high H3K27me3 level (Figure 2d). The gene discussed is FAM161A; the disease is retinal degeneration.