On the other hand, muscle-specific IR KO mice develop metabolic syndrome features, including high triglycerides and free fatty acids circulating levels, although they do not show altered glucose tolerance, thus indicating that other organs, such as the liver and adipose tissue, are able to compensate skeletal muscle insulin resistance to avoid hyperglycaemia and hyperinsulinemia, leading to T2D [122]. Here, INS is linked to type 2 diabetes mellitus.