A group of metabolic pathways, including those of carbohydrates, lipids, nucleotides, amino acids, glycans, cofactors, vitamins, biosynthesis of terpenoids, polyketides and other secondary metabolites [25], as well as signaling pathways related to metabolic disturbances and the development of neoplasia and T2D, such as mTOR, AMPK, PI3K-Akt and insulin signaling pathways, were also among the ontologies significantly regulated by the AML/T2D gene set. This evidence concerns the gene AKT1 and acute myeloid leukemia.