Increased numbers of circulating TF-positive or annexin V-positive MPs derived from endothelial cells or platelets and shorter clotting times were also observed in carriers of a common prothrombin gene mutation (G20210A) [197] or factor V Leiden (FVL) gene mutations [198], known to predispose to venous thromboembolism. Here, F2 is linked to venous thromboembolism.