TF and neoplasm: Findings that mice with TF-positive tumors and elevated levels of circulating TF-positive EVs exhibited increased thrombosis in a saphenous vein model, whereas no differences in thrombus weight were observed between tumor-bearing and control mice in the inferior vena cava stenosis model [237] suggest that the IVC ligation model of venous stasis may not be ideal to examine the role of circulating factors in the pathophysiology of venous thrombosis [238].