Time course analysis revealed markedly elevated circulating levels of PS-positive procoagulant MPs, primarily of those expressing the platelet marker GPIb, and to a lesser extent of those positive for the endothelial marker CD31, at day 0 in patients during STEMI and unstable angina, which subsequently decreased following treatment (i.e., percutaneous coronary angioplasty (PTCA) and GPIIbIIIa inhibitors), but still were significantly elevated at day 6 after the initial event [170]. This evidence concerns the gene PECAM1 and angina unstable.