TIMP1 and neoplasm: In addition, other studies have also shown that the expression of TIMPs, especially TIMP-1, is increased in several types of tumors, and this increase in its expression has been correlated with a poor prognosis of these tumors [9,10,11,12,13,14,15,16,17], which goes against the initial concept that TIMPs, including TIMP-1, could prevent tumor progression and metastasis.