TIMP1 and neoplasm: Initially, these data seemed unexpected, but today it is known that TIMP-1 is a multifunctional protein that can promote proliferation, growth, survival, regulate differentiation, and inhibit apoptosis in several tumor types, including Non-Small Cell Lung Cancer, osteosarcoma (MG-63 cell line), colorectal, human gastric cancer, and breast cancer (T-47D, MCF-7, and MDA-MB-231 cell lines) [10,11,14,15,17,90,91,92,93].