This last result supports the idea that aberrant N-glycosylation, specifically, the presence of the terminal branch β-1,6-N-acetylglucosamine (β-1,6-GlcNAc), added by the enzyme N-acetylglucosaminyltransferase-V (GnT-V), is essential for TIMP-1 to be able to activate signal transduction pathways that induce cell proliferation, growth, and survival and culminate in tumor progression. This evidence concerns the gene TIMP1 and neoplasm.