The discovery that the TIMP-1/CD63/β1-integrin complex activates the YAP/TAZ signaling pathway to promote the proliferation of different types of cancer cells gives us new insights to understand the molecular pathways involved in the oncogenic role of this complex, in addition to demonstrating that the TIMP-1/YAP/TAZ axis might be considered a new therapeutic target for cancer patients. This evidence concerns the gene CD63 and cancer.