In 2017, Tobe et al. performed protein profiling of hiPSC-derived neurons from seven LR BD patients, three lithium NR BD patients, and seven control individuals to assess the role of lithium in the phosphorylation status of CRMP2. Using 2D-differential gel electrophoresis (2D-DIGE) and several pathway analysis (ingenuity pathway analysis and STRING network tool), they observed that the ratio of inactive phosphorylated CRMP2 (pCRMP2): active non-phosphorylated CRMP2 was elevated in hiPSC-derived neurons from LR BD patients compared to lithium NR BD neurons. Here, DPYSL2 is linked to Behcet disease.