Notably, AdoMet-induced activation of caspase 8 observed in 5-FU-treated HCT 116p53+/+ and LoVo cells is in agreement with literature data indicating that p62 accumulation, caused by autophagy impairment, promoted caspase 8 activation during cisplatin-induced apoptosis in ovarian cancer cells resulting in enhanced sensitivity to the chemotherapeutic drug [45]. This evidence concerns the gene CASP8 and ovarian cancer.