Analogous to ribosomopathies, several congenital disorders also exhibit p53 upregulation, including Fanconi anemia (FA, with genetic defects in DNA damage repair and response), dyskeratosis congenita (DC, telomere replication defects), and primary microcephaly (centrosome duplication defects) [41,42,43]. The gene discussed is TP53; the disease is dyskeratosis congenita.