As shown in Figure 1A,D,E, and Table 1, a comparison with healthy controls demonstrated an increasing median proportion of CD4 T cells expressing PD-1 checkpoint in all MM patients regardless of cell subsets (both Teff and Treg cells defined as CD4+CD127+ and CD4+CD127− T cells, respectively) (p < 0.05). This evidence concerns the gene CD4 and Miyoshi myopathy.