Similarly, Zheng et al. [48] found that an (AT)n microsatellite polymorphism within the 3ʹ-untranslated region (UTR) of exon 3 of the CTLA-4 gene might represent a susceptibility locus for MM, as the increased frequencies of the alleles containing extended AT repeats seen in MM patients are associated with lower CTLA-4 mRNA stability and protein expression. This evidence concerns the gene CTLA4 and Miyoshi myopathy.