In a study by Chandra et al., the enrichment of differentially methylated CpGs in several psoriasis susceptibility regions (PSORS) was observed with the use of genomic DNA methylation profiling in psoriasis patients (top differentially methylated genes overlapped with PSORS regions including S100A9, SELENBP1, CARD14, KAZN and PTPN22). The gene discussed is CARD14; the disease is psoriasis.