A second hypothesis underlying RYR2-dependent CPVT proposes that RYR2 variants cause an impaired binding affinity of the FKBP12.6, a protein involved in stabilizing a closed state of the RyR2 channel during diastole, to the RyR2 monomers (Figure 3B) [65]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.