RYR2 and catecholaminergic polymorphic ventricular tachycardia: Despite the commonality in the mechanism that leads to DADs underlying CPVT arrhythmogenesis, several hypotheses, likely influenced by the location of the RYR2 variants and their effect on structure, gating, and regulation of the channel, have been outlined to converge to this conclusion (Figure 3) [60,61].