Moreover, cytokines regulated by STAT3 in tumor microenvironment, like IL-6, IL-10, VEGF and TGF-β, trigger a positive feed-back amplification of STAT3 in multiple types of cells throughout the tumor microenvironment, finally resulting in severer tumor growth and immuno-suppression [1,4,5,8,9,10,11]. This evidence concerns the gene TGFB1 and neoplasm.