There was a significant difference in tumor development and metastasis in mice injected with NLRP3 WT(+/+) SK-Hep1 Luc cells as compared with mice injected with NLRP3 KO(−/−) HCC cells beginning in the fifth week, and this difference increased when the mice were treated with NK-92 cells. Here, NLRP3 is linked to hepatocellular carcinoma.