Indeed, overexpression of Cripto-1 decreased E-cadherin expression and increased the expression of Vimentin, N-cadherin, β-catenin, ZEB-1, and Snail, as well as the matrix metalloproteinases (MMP-2 and MMP-9) that are involved in tumor invasion and metastasis due to their role in degrading the extracellular matrix [60]. This evidence concerns the gene CDH1 and neoplasm.