AKT1 and cervical carcinoma: Interestingly, treatment of SiHa and Ca Ski cervical carcinoma cells with Cripto-1 induces hyperphosphorylation of AKT leading to anti-apoptotic effects suggesting a role for Cripto-1 as a survival factor in cervical malignancies through a PI3K/Akt/GSK-3β pathway [64].