In colorectal cancer (CRC), the depletion of p53 prevents the nuclear accumulation of dipeptidyl peptidase-4 (DPP4), and consequently, binding to the membrane-related DPP4-mediated trigger NADPH oxidase 1 (NOX1), thereby inducing lipid peroxidation and ferroptosis [23]. The gene discussed is DPP4; the disease is colorectal carcinoma.