CAD and juvenile Huntington disease: Another candidate gene from Cps that could serve to influence expression levels of downregulated genes shows similarity to RNQ1 (Table 2; Figure 1A, Figure 2B), a prion encoding gene that is thought to have a role in epigenetics and phenotypic changes in Saccharomyces cerevisiae, and which also mediates polyQ aggregation in concert with heat shock proteins in a Huntington’s Disease yeast model [36,37].