Accordingly, this opto-TLR4 PANC 1 reporter cell line offers a novel tool for analysing the role of TLR4 signalling in tumour invasion and metastasis, thereby enhancing our understanding of the pathogenesis of pancreatic cells, and providing clues for developing new strategies against TLR4-mediated metastasis. The gene discussed is TLR4; the disease is neoplasm.