Further data linking altered NCT to C9-ALS include the following: nuclear RNA retention [46,52], mislocalization of Pom121 by poly-GA [49], reduced nuclear RCC1 (RanGEF) in C9orf72-carrier induced neurons [47], and increased cytoplasmic localization of neuronal RNA-binding protein Elav [53]. The gene discussed is C9; the disease is amyotrophic lateral sclerosis.