MAPT and early-onset autosomal dominant Alzheimer disease: Proteolytic cleavage of specific proteins is the common denominator of many neurodegenerative diseases including huntingtin protein in Huntington’s disease [386,387], α-synuclein in Parkinson’s disease and Lewy body dementia [388], ataxins in cerebral ataxia [389,390], prion protein in prionosis [391,392] and tau protein in Alzheimer’s disease, as mentioned in Section 1 [117].