There are also reports of SAHA promoting EMT through the HDAC8/FOXA1 axis in triple-negative MDA-MB-231 and BT-549 breast cancer cells, in which SAHA upregulated the mesenchymal markers N-cadherin, vimentin, and fibronectin and downregulated E-cadherin expression [61]. Here, HDAC8 is linked to breast cancer.