Shortly after the first reports of a significantly upregulated miRNA-146a in AD-affected brain and IL-1β-, TNFα- and/or Aβ42 peptide-stressed human neuronal–glial (HNG) cells (transplantation grade) in primary co-culture, the increased abundance of this same pro-inflammatory sncRNA was reported by multiple groups in animal and human nervous tissues affected with PrD [10,54,55,63,75,101]. The gene discussed is IL1B; the disease is X-linked retinal dysplasia.