miRNA-146a upregulation in transfected co-cultures of neuronal–glial cells can downregulate both CFH mRNA and protein levels via miRNA-146a pairing with 3′-UTR of human CFH, a finding also observed in multiple murine transgenic models for neural degeneration and in human AD, AMD, MS and TLE [10,22,24,104]. The gene discussed is CFH; the disease is Alzheimer disease.