Additionally, while T helper 2 (TH2) cells promote differentiation of tumor-infiltrating monocytes and macrophages into pro-angiogenic tumor-associated macrophages (TAMs), Th1 and Cytotoxic T cells secrete interferon-γ (IFNγ), which inhibits tumor angiogenesis by restricting the proliferation of endothelial cells [147]. The gene discussed is IFNG; the disease is neoplasm.