Correspondingly, strong cross-communication between endothelial and immune cells during inflammation has also been reported with certain immune cells, e.g., neutrophils and monocytes, reported to play essential roles in inflammation-associated angiogenesis; they also constitute important sources of pro-angiogenic factors such as VEGFA, FGF2, and MMP9, and STAT3-mediated signaling, especially during tumor development [142,143]. This evidence concerns the gene VEGFA and neoplasm.