As a result of evaluating MMP-13 mRNA expression in cancer tissues of CRC patients by the membrane array method, the stage of cancer progression is significantly associated with MMP-13 overexpression, and it was confirmed that patients with MMP-13 overexpression had a 7.989-times higher risk of recurrence after surgical resection compared with patients without MMP-13 overexpression [104]. Here, MMP13 is linked to cancer.