The majority of TNNC1 variants are located in the EF-hands, with the exception of A8V, located near the N-terminus and leading to dilated cardiomyopathy, and L29Q, located at the putative interaction site for cTnI and therefore hindering the interaction between cTnI and cTnC, leading to hypertrophic cardiomyopathy (Figure 2A) [46,47,48,49]. This evidence concerns the gene TNNI3 and hypertrophic cardiomyopathy.