As MEG3 was mainly expressed in the cytoplasm, the authors speculated that it might act as a sponge for miRNAs, including miR-7-5p, which was important for RPE changes and AMD progression through the interaction with PAX6, which is important for the RPE differentiation by mediating pigmentation and hyperproliferation in the transdifferentiated RPE [77]. Here, MEG3 is linked to age-related macular degeneration.