T cells transduced with TCR for NPM1-mutated protein also efficiently killed AML cells in an in vivo xenograft murine model, resulting in prolonged OS of immunodeficient NSG mice engrafted with HLA-A*02:01-positive NPM1-mutated OCI-AML3 human cells, in comparison to untreated mice or mice treated with CMV-specific TCR [20]. Here, NPM1 is linked to acute myeloid leukemia.