Subsequently, in order to evaluate the dynamics of specific immune responses throughout the disease course, Forghieri et al., collected PB and BM samples from NPM1-mutated AML patients at different timepoints [19], whereas in the former study by Greiner et al., the presence of NPM1-mutated-specific T cells was investigated in a single PB sample per patient [16]. Here, NPM1 is linked to acute myeloid leukemia.