NPM1 and acute myeloid leukemia: In conclusion, even though it has thoroughly been documented that NPM1-mutated protein is immunogenic and may elicit neoantigen-specific immune responses in vivo, further prospective studies are warranted to investigate whether individualized anti-leukemic immunotherapeutic approaches could have a potential clinical utility in NPM1-mutated AML patients throughout their disease course [1,3,4,19,20,70].