This latter observation is not surprising since it has recently been reported that infiltration by T-cell population, using immunohistochemical examinations, appeared to be quantitatively preserved in BM specimens from AML patients compared with healthy donors, even though an increased proportion of T-regulatory cells (Tregs) and higher frequency of PD1/CD8+ T cells coexpressing TIM3 or LAG3 immune-checkpoint molecules were documented by flow cytometry in AML patients, mainly in relapsed/refractory cases [43,44]. This evidence concerns the gene LAG3 and acute myeloid leukemia.