Upregulation of sEng in confirmed preeclampsia and in pregnancies prior to symptom onset.Midpregnancy urinary PlGF levels correlates with the consequent preterm PE development.Thrombocytopenia, haemolysis and HELLP was noted as a severe PE outcome in animals treated with both sFLT1 and sEng.sEng upregulated in PE patients with severe complications including placental abruption, HELLP syndrome, eclampsia and IUGR. This evidence concerns the gene PGF and HELLP syndrome.