PGF and fetal growth restriction: Upregulation of sEng in confirmed preeclampsia and in pregnancies prior to symptom onset.Midpregnancy urinary PlGF levels correlates with the consequent preterm PE development.Thrombocytopenia, haemolysis and HELLP was noted as a severe PE outcome in animals treated with both sFLT1 and sEng.sEng upregulated in PE patients with severe complications including placental abruption, HELLP syndrome, eclampsia and IUGR.