Circulating sFlt-1 levels upregulated in preeclampsia prior to delivery and is reduced to baseline 48–72 h postdelivery.High sFlt-1 levels correlate inversely with decreased free PlGF levels during preeclampsia.Circulating PlGF levels are downregulated in PE and correlated elevation in total VEGF-A with soluble VEGFR-1.Membrane-bound VEGFR1 is reduced in the placental bed and correlates with poor uteroplacental progression.Upregulation of new sFlt-1 isoforms with differing mRNA lengths in preeclamptic placentas.Circulating sFlt-1-14 identified as a major VEGF inhibitor in PE. The gene discussed is PGF; the disease is preeclampsia.