SMIM20 and Anxiety: Similar to phoenixin, nesfatin-1 has effects on various physiological functions such as food intake [40,47], anxiety [48], duodenal [49] and gastric motility [47], influence on gonadotropins/sexual maturation [50,51], and on inflammation accompanied by reductions in TNF-α and interleukin levels, as well as an involvement in cyclooxygenase 2 signaling [52,53,54,55].