SCRIB and cancer: The E6 encoded by HR HPVs plays a pivotal role in this cancer hallmark as it downregulates proteins modulating cell polarity and motility such as the scribbled planar cell polarity protein (SCRIB) involved in cell polarization and differentiation, and the membrane-associated guanylate kinases 1, 2, and 3 (MAGI-1, 2 and 3) [50].