We also concurred to describe other immune-reactivities reported in a minor proportion of MG patients, that can be co-existing with anti-AChR Abs and/or anti-MuSK Abs, targeting acetylcholinesterase [19] and the low-density lipoprotein receptor-related protein 4 LRP4 [20] with a contribution to improve the management of disease. The gene discussed is MUSK; the disease is myasthenia gravis.