NR1H4 and metabolic dysfunction-associated steatotic liver disease: Given that farnesoid X receptor (FXR), the receptor for bile acids, plays a pivotal role in maintaining bile acid, lipid, and glucose homeostasis, it is not surprising that FXR-deficient mice developed NAFLD phenotypes, and patients with metabolic disorders had decreased level of FXR expression in their liver and intestine [271,272].