THOP1 and early-onset autosomal dominant Alzheimer disease: Table 1 summarizes the top five canonical pathways; and include communication between innate and adaptive immune cells, CREB signaling in neurons, hematopoiesis from pluripotent stem cells, the neuroprotective role of THOP1 in Alzheimer’s disease, and primary immunodeficiency signaling. The p value and the list of the specific genes differentially expressed for each pathway are also depicted in the table.