This treatment is effective at treating osteoporosis; however, our previous studies, and our current study in Scl-Ab-treated mice, studies in hematopoietic differentiation in older Sost−/− mice, and long-term studies in WT→Sost−/− chimeras suggest that this treatment may have unintended effects on immune development of patients, many of whom are older and have less plastic immune systems [54]. This evidence concerns the gene SOST and osteoporosis.