Aging is also associated with a chronic inflammatory phenotype that has been characterized by anemia, immunosenescense, and thrombocytosis [23], as well as overproduction of the inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factorα (TNFα), and interleukin-6 (IL-6) [24]. The gene discussed is IL1A; the disease is anemia (phenotype).