JUP and Mental deterioration: Whereas Ide et al. [31] showed that in AD patients the presence of PD is associated with a marked increase in cognitive decline, and reported evidence of a relative increase in pro-inflammatory status and a decrease in anti-inflammatory status over a 6-month follow-up period in participants with PD, they did not show a significant relationship between Pg antibody serum levels and the rate of cognitive decline, while others have shown a link between AD and certain periodontal pathogens [27,28,30].